The 7.2 magnitude quake was centered about 200 miles southwest of Quetta, near the small Balochistan community of Dalbandin, where about 200 mud houses sustained damage.
The U.S. Geological Survey placed the depth of the quake at just a little over 50 miles.
Residents in Quetta said the shaking lasted for about 20 seconds, sending people rushing outdoors from their beds at 1:23 a.m. local time.
The only reported fatality was that of a female cardiac patient who died of a heart attack during the quake.
Buildings in the Gulf emirate of Dubai, nearly 500 miles to the southwest, also shook for about 30 seconds.
Pakistan is still recovering from catastrophic flooding that submerged about a third of the country last summer.
The area in Balochistan province surrounding the center of Wednesday morning’s temblor is also reported to be the home of a heavy Taliban insurgency force.