Chinese media reports the 6.9 magnitude temblor also killed 185 head of livestock and forced the temporary suspension of rail service while tracks were inspected.
It was one of several quakes over a two-day period that were felt by residents in Hotan, Yutian and Moyu, Xinhua reported.
The U.S. Geological Survey said the strongest quake, which hit at 5:19 p.m. local time, was centered about 167 miles east-southeast of Hotan at a depth of about 6 miles.
Another tremor of magnitude 5.7 struck five minutes later, about 3 miles beneath the surface and was followed by a series of aftershocks of up to 4.2 magnitude.
The epicenters in Yutian county were beneath a mountainous area thousands of feet above sea level on the edge of the Taklamakan desert.